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Mouse Anti-Human NMP-22 IgM Monoclonal Antibody (SPM300) (CAT#: NGM-397)

This product is an unconjugated anti-Human NMP-22 Monoclonal antibody (SPM300) generated from the Mouse. This antibody can be used for FC, IF, IHC.

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specifications

Antibody Isotype IgM, κ
Clone SPM300
Applications FC; IF; IHC
Target NMP-22
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human
Immunogen Colon carcinoma 174T cells
Format Liquid
Buffer 10 mM PBS with 0.05% BSA
Storage Store at 4° C.

Target Information

Target Name NMP-22
Alternative Names Nuclear Mitotic Apparatus Protein 1; Nuclear Matrix Protein-22; SP-H Antigen; NUMA; Centrophilin Stabilizes Mitotic Spindle In Mitotic Cells; Nuclear Mitotic Apparatus Protein; Structural Nuclear Protein; NuMA Protein; NUMA1; NMP22
Related Disease Acute Promyelocytic Leukemia; Deafness Autosomal Recessive 63
Gene ID 4926
UniProt ID Q14980
Target Overview Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division. Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles. Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner. In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle. During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation. Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro. Also required for proper orientation of the mitotic spindle during asymmetric cell divisions. Plays a role in mitotic MT aster assembly. Involved in anastral spindle assembly. Positively regulates TNKS protein localization to spindle poles in mitosis. Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume. Required for epidermal differentiation and hair follicle morphogenesis.
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!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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