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Mouse Anti-Human Mucin-4 IgM Monoclonal Antibody (CBFYM-0252) (CAT#: NGM-308)

This product is an unconjugated anti-Human Mucin-4 Monoclonal antibody (CBFYM-0252) generated from the Mouse. This antibody can be used for ELISA, FC, IHC, IP.

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specifications

Antibody Isotype IgM
Clone CBFYM-0252
Applications ELISA; FC; IHC; IP
Target Mucin-4
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human
Immunogen Coll2-23 colorectal cancer cells and live PC/AA polyposis coli cells
Format Liquid
Buffer PBS
Storage Store at 4° C for short term and at -20° C or lower for long term. Avoid freeze-thaw cycles.

Target Information

Target Name Mucin-4
Alternative Names Mucin 4 Cell Surface Associated; Pancreatic Adenocarcinoma Mucin; Mucin 4 Tracheobronchial; Ascites Sialoglycoprotein; Tracheobronchial Mucin; Testis Mucin; MUC-4; ASGP; HSA276359; MUC4
Related Disease Filamentary Keratitis; Biliary Tract Cancer
Gene ID 4585
UniProt ID Q99102
Target Overview May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.
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!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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