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This product is an unconjugated anti-Human HLA-B Monoclonal antibody (EP-4) generated from the Mouse. This antibody can be used for FC, IF.
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specifications |
|
|---|---|
| Antibody Isotype | IgM, κ |
| Clone | EP-4 |
| Applications | FC; IF |
| Target | HLA-B |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Lymphocytes from an HLA-B27 patient |
| Format | Liquid |
| Buffer | 10 mM PBS with 0.05% BSA |
| Storage | Store at 4° C. |
Target Information |
|
|---|---|
| Target Name | HLA-B |
| Alternative Names | Major Histocompatibility Complex, Class I, B; HLA Class I Histocompatibility Antigen B Alpha Chain; HLAB; MHC Class I Antigen HLA-B Alpha Chain; MHC Class I Antigen HLA-B Heavy Chain; MHC HLA-B Transmembrane Glycoprotein; MHC HLA-B Cell Surface Glycoprotein; Leukocyte Antigen Class I-B; HLA Class I Antigen HLA-B; MHC Class I Antigen SHCHA; Human Leukocyte Antigen B; Ankylosing Spondylitis; MHC Class I Molecule; MHC Class 1 Antigen; B-4901 |
| Related Disease | Severe Cutaneous Adverse Reaction; Spondyloarthropathy 1 |
| Gene ID | 3106 |
| UniProt ID | P01889 |
| Target Overview | Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity. Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells. Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9. |
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Datasheet