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Mouse Anti-Human CD43 IgM Monoclonal Antibody (Bra7G) (CAT#: NGM-396)

This product is an unconjugated anti-Human CD43 Monoclonal antibody (Bra7G) generated from the Mouse. This antibody can be used for FC, IF, IHC.

Please feel free to contact us for a quote and further discussion with our scientists. Datasheets

specifications

Antibody Isotype IgM, κ
Clone Bra7G
Applications FC; IF; IHC
Target CD43
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human
Immunogen Immature pluripotent human leukemia K562 cells
Format Liquid
Buffer 10 mM PBS with 0.05% BSA
Storage Store at 4° C.

Target Information

Target Name CD43
Alternative Names Sialophorin; Leukosialin; GPL115; Sialophorin (GpL115 Leukosialin CD43); Leukocyte Sialoglycoprotein; Galactoglycoprotein; GALGP; LSN; CD43 Antigen; SPN
Related Disease Adenoid Basal Cell Carcinoma; Wiskott-Aldrich Syndrome
Gene ID 6693
UniProt ID P16150
Target Overview Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1. It protects cells from apoptotic signals, promoting cell survival.
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!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

!! Custom antibodies beyond the list can be tailored flexibly. Please directly Email us your specific demands.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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