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Mouse Anti-Human CD41/CD61 Monoclonal Antibody (PAC-1)

Mouse Anti-Human CD41/CD61 Monoclonal Antibody (PAC-1) (CAT#: NGM-380)

This product is an unconjugated anti-Human CD41/CD61 Monoclonal antibody (PAC-1) generated from the Mouse. This antibody can be used for FC, IF, IP.

Please feel free to contact us for a quote and further discussion with our scientists. Datasheets

specifications
Antibody Isotype IgM, κ
Clone PAC-1
Applications FC; IF; IP
Target CD41/CD61
Epitope This antibody recognizes an activation-induced conformational epitope PAC-1.
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
species Reactivity Human
Immunogen Human platelets
Format Liquid
Buffer TBS, pH 8.0
Storage Store at 4° C for short term and at -20° C or lower for long term. Avoid freeze-thaw cycles.
Target Information
Target Name CD41/CD61
Alternative Names Integrin Subunit Alpha 2b; Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen CD41); Platelet Glycoprotein IIb Of IIb/IIIa Complex; Protein Phosphatase 1, Regulatory Subunit 93; Platelet Membrane Glycoprotein IIb; Integrin Alpha-IIb; GPalpha IIb; PPP1R93; CD41B; GPIIb; CD41; GP2B; Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen CD41B); Platelet Fibrinogen Receptor Alpha Subunit; Platelet-Specific Antigen BAK; AlphaIIb Protein; CD41 Antigen; BDPLT16; BDPLT2; ITGA2B; ITGAB; HPA3; GTA
Related Disease Glanzmann Thrombasthenia 1; Bleeding Disorder, Platelet-Type 16
Gene ID 3674
UniProt ID P08514
Target Overview Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

KINDLY NOTE
!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

!! Custom antibodies beyond the list can be tailored flexibly. Please directly Email us your specific demands.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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