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Mouse Anti-Human CD160 Monoclonal Antibody (BY55)

Mouse Anti-Human CD160 Monoclonal Antibody (BY55) (CAT#: NGM-300)

This product is an unconjugated anti-Human CD160 Monoclonal antibody (BY55) generated from the Mouse. This antibody can be used for FC, IP.

Please feel free to contact us for a quote and further discussion with our scientists. Datasheets

Antibody Isotype IgM, κ
Clone BY55
Applications FC; IP
Target CD160
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
species Reactivity Human
Immunogen Human NK cell line YT2C2
Format Liquid
Buffer PBS, pH 7.4
Storage Store at 4° C for short term and at -20° C or lower for long term. Avoid freeze-thaw cycles.
Target Information
Target Name CD160
Alternative Names CD160 Molecule; BY55; Natural Killer Cell Receptor BY55; NK28; NK1; Natural Killer Cell Receptor, Immunoglobulin Superfamily Member; CD160-Delta Ig
Related Disease Neurotrophic Keratopathy; Cone-Rod Dystrophy 1
Gene ID 11126
UniProt ID O95971
Target Overview Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. Receptor for both classical and non-classical MHC class I molecules. In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response. On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells. Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion. On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites. Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response. On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.






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