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This product is an unconjugated anti-Human Angiostatin Monoclonal antibody (GMA-013) generated from the Mouse. This antibody can be used for WB, ELISA.
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specifications |
|
|---|---|
| Antibody Isotype | IgM |
| Clone | GMA-013 |
| Applications | WB; ELISA |
| Target | Angiostatin |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Purified human plasminogen |
| Format | Lyophilized |
| Buffer | PBS with 1% mannitol, pH 7.4 |
| Storage | Store at -20° C to -80° C. Avoid freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | Angiostatin |
| Alternative Names | Plasminogen; Plasmin; PLG |
| Related Disease | Plasminogen Deficiency Type I; Plg-Related Hereditary Angioedema With Normal C1inh |
| Gene ID | 5340 |
| UniProt ID | P00747 |
| Target Overview | Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. |
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Datasheet