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Mouse Anti-Fibrin Monoclonal Antibody (UC45)

Mouse Anti-Fibrin Monoclonal Antibody (UC45) (CAT#: NGM-289)

This product is an unconjugated anti-Fibrin Monoclonal antibody (UC45) generated from the Mouse. This antibody can be used for WB, IF, IHC, RIA.

Please feel free to contact us for a quote and further discussion with our scientists. Datasheets

Antibody Isotype IgM
Clone UC45
Applications WB; IF; IHC; RIA
Target Fibrin
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
species Reactivity Human, Rat
Immunogen Human acute monoblastic leukemia cells
Format Liquid
Buffer PBS
Storage Store at 4° C.
Target Information
Target Name Fibrin
Alternative Names Fibrinogen Alpha Chain; Fibrinogen A Alpha Polypeptide; Fib2; FGA
Related Disease Dysfibrinogenemia Congenital; Afibrinogenemia Congenital
Gene ID 2243
UniProt ID P02671
Target Overview Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.






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