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Anti-Human KEAP1 IgA Monoclonal Antibody (4G10H9) (CAT#: NGA-033)

This product is an unconjugated anti-human KEAP1 monoclonal antibody gernerated from the mouse. This antibody can be used for applications: Western Blotting, Immunohistochemistry, Immunofluorescence, ELISA.

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specifications

Antibody Isotype IgA
Clone 4G10H9
Applications WB; IHC; IF; ELISA
Target KEAP1
Host Mouse
Clonality Monoclonal
Antibody Type Primary antibody
Species Reactivity Human, Rat, Mouse
Immunogen KEAP1 fusion protein
Format Liquid
Buffer PBS with 50% glycerol, pH7.3
Storage Store at -20°C.

Target Information

Target Name KEAP1
Alternative Names Kelch Like ECH Associated Protein 1; KLHL19; INrf2; Kelch-Like ECH-Associated Protein 1; Kelch-Like Family Member 19; Cytosolic Inhibitor Of Nrf2; Kelch-Like Protein 19; KIAA0132; KEAP1 Delta C; INRF2
Related Disease Goiter Multinodular 1 With Or Without Sertoli-Leydig Cell Tumors; Papillary Adenocarcinoma
Gene ID 9817
UniProt ID Q14145
Target Overview Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation. The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome.
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KINDLY NOTE
!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

!! Custom antibodies beyond the list can be tailored flexibly. Please directly Email us your specific demands.

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For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.

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