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This product is an unconjugated anti-human CD3 ε monoclonal antibody gernerated from the human. This antibody can be used for Flow Cytometry/FACS.
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specifications |
|
|---|---|
| Antibody Isotype | IgA, κ |
| Clone | NGA13H-TT |
| Applications | FC |
| Target | CD3E |
| Host | Human Immunodeficiency Virus |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| Species Reactivity | Human |
| Immunogen | Human peripheral E+ cells |
| Format | Liquid |
| Buffer | PBS |
| Storage | Store at 4°C for short-term and -20°C for long-term. Avoid repeated freeze-thaw cycles. |
Target Information |
|
|---|---|
| Target Name | CD3E |
| Alternative Names | CD3e Molecule; CD3e Antigen Epsilon Polypeptide (TiT3 Complex); T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain; CD3e Molecule, Epsilon (CD3-TCR Complex) 2; T3E; T-Cell Antigen Receptor Complex, Epsilon Subunit Of T3; CD3e Antigen; CD3-Epsilon; IMD18; TCRE |
| Related Disease | Immunodeficiency 18; T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta |
| Gene ID | 916 |
| UniProt ID | P07766 |
| Target Overview | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. |
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Datasheet