This product is an unconjugated anti-human BAX (N-Term) monoclonal antibody gernerated from the mouse. This antibody can be used for applications: Flow Cytometry/FACS, Immunocytochemistry, Immunohistochemistry, Western Blotting.
Please feel free to contact us for a quote and further discussion with our scientists. Datasheets
| specifications | |
|---|---|
| Antibody Isotype | IgA |
| Clone | NGA04-TT |
| Applications | FC; ICC; IHC; WB |
| Target | BAX |
| Host | Mouse |
| Clonality | Monoclonal |
| Antibody Type | Primary antibody |
| species Reactivity | Human, Mouse |
| Immunogen | A synthetic peptide (KLH-coupled) corresponding to N-terminal Bax. |
| Format | Liquid |
| Buffer | TBS, pH 7.4, 1% BSA, 40 %Glycerol |
| Storage | Store at 4°C for short-term and -20°C for long-term. Avoid repeated freeze-thaw cycles. |
| Target Information | |
|---|---|
| Target Name | BAX |
| Alternative Names | BCL2 Associated X, Apoptosis Regulator; BCL2L4; BCL2 Associated X Protein; Apoptosis Regulator BAX; Bcl-2-Like Protein 4; Bcl2-L-4; BCL2-Associated X Protein Omega; BCL2-Associated X Protein; Baxdelta2G9 |
| Related Disease | T-Cell Acute Lymphoblastic Leukemia; Colorectal Cancer |
| Gene ID | 581 |
| UniProt ID | Q07812 |
| Target Overview | Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. |
KINDLY NOTE
!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.
!! Custom antibodies beyond the list can be tailored flexibly. Please directly Email us your specific demands.
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