This product is an unconjugated anti-human Androgen Receptor monoclonal antibody gernerated from the mouse. This antibody can be used for Western Blotting.
Please feel free to contact us for a quote and further discussion with our scientists. Datasheets
|Antibody Type||Primary antibody|
|Immunogen||Purified His-tagged androgen receptor protein fragment|
|Storage||Store at -20°C.|
|Target Name||Androgen receptor|
|Alternative Names||Dihydrotestosterone Receptor; NR3C4; Nuclear Receptor Subfamily 3 Group C Member 4; HUMARA; SMAX1; DHTR; AIS; Spinal And Bulbar Muscular Atrophy; Testicular Feminization; HYSP1; SBMA; AR8; TFM; KD; AR|
|Related Disease||Androgen Insensitivity Partial; Spinal And Bulbar Muscular Atrophy, X-Linked 1|
|Target Overview||Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.1 Publication
In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
Transcriptional activity is enhanced by binding to RANBP9.
The level of tyrosine phosphorylation may serve as a diagnostic tool to predict patient outcome in response to hormone-ablation therapy. Inhibition of tyrosine phosphorylation may be an effective intervention target for hormone-refractory prostate cancer.
!! For Research Use Only. Our products and services are NOT intended for diagnostic or therapeutic applications.
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